WELLSIM BIOMEDICAL TECHNOLOGIES INC — Department of Health and Human Services SBIR Phase I: 400
WELLSIM BIOMEDICAL TECHNOLOGIES INC — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $256,474
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- 400
- Solicitation
- PA20-272
- NAICS
- —
- Place of performance
- CA
- Period
- 2022-03-01 → 2022-10-31
Description
PROJECT SUMMARY / ABSTRACT Exosomes, the small extracellular vesicles (30-200 nm), are highly heterogeneous in biofluids. However, traditional bulk-level analysis approaches fail to represent their individual variations. A technique for multi-omics profiling of exosomes at single-particle resolution is of great interest to the exosome research field, but has yet to be developed. WellSIM proposes to develop and validate a method for multi-omics profiling of individual exosomes based on our exosome isolation system (EXODUS), a droplet-based microfluidic device (EXOSeq), and next-generation sequencing (NGS). Our proposed technique will be the first integrative proteomic and transcriptomic profiling of exosomes at the single-particle level, offering high-resolution multi-dimensional biological insights for exosome study and application.