TEICHOS LABORATORIES, LLC — Department of Health and Human Services SBIR Phase I: NCIRD
TEICHOS LABORATORIES, LLC — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $243,000
- Agency
- Department of Health and Human Services · Centers for Disease Control and Prevention
- Program / Phase
- SBIR · Phase I
- Topic
- NCIRD
- Solicitation
- PA20-260
- NAICS
- —
- Place of performance
- IN
- Period
- 2021-09-30 → 2022-09-29
Description
ABSTRACT: Teichos technology, amacromolecularplatformofpeptidoglycanbiologics(sPGN)producedbyproprietary chemoenzymatictotalsynthesis,offersimprovedinfluenzavaccinesthroughsignificantlyimprovedadjuvant performance. TL-001, a stimulatory sPGN, demonstrated adjuvant activity at low doses in standard laboratory vaccination model. We propose to evaluate TL-001 for its potential utility as an influenza vaccine adjuvant by confirming its mechanism of action in monocyte and macrophage cultures and its ability to enhance antibody and T cell responses using an influenza H1 subunit vaccination model in mice.