DETROIT R & D, INC. — Department of Health and Human Services SBIR Phase II: NCI
DETROIT R & D, INC. — SBIR Phase II award from Department of Health and Human Services.
- Amount
- $10,338
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- NCI
- NAICS
- —
- Place of performance
- MI
- Period
- —
Description
O GlcNAcylation of proteins plays a critical role in cell cycle regulationapoptosis and signal transductionModification of O GlcNAcylation of proteins by O GlcNAc transferase is reversible by the activity of O GlcNAcaseAddition and removal of O GlcNAc moiety to serine or threonine regulate the function of proteins directly or via decreased phosphorylationO GlcNAcylation of c myc proteins induces ubiquitin dependent c myc degradationGlcNAcylation of pprevents pdegradation and stabilizes pproteinswhich are beneficial in cancer cells by arresting cell growth and inducing apoptosis in response to DNA damageTo elucidate functions of O GlcNAcylation of the proteins it is necessary to develop site specific antibodies for O GlcNAcylated proteinsFew site specific antibodies have been successfully produced so farA lack of site specific O GlcNAcylated Abs prevents facile detection and quantitation of the site to elucidate the function of O GlcNAcylated molecules in physiology and diseaseAvailability of O GlcNAcylation site specific antibodies will facilitate mechanistic studies on O GlcNAcylationand phosphorylation dependent signal transduction pathway in cancerwhich will result in development of O GlcNAcylation inducing anti cancer drugs