MYEXPOSOME INC — Department of Defense SBIR Phase II: DHP15-009

Description

Thelack of low cost,maintenance-free,easy-to-wear personal samplingtechnology hinders assessment ofchemicalexposuresespecially in deployed military populations.We are developing a silicone wristband for use as a passivemonitor forenvironmentalexposure. Silicone wristband personal dosimeters (PDs) are uniquein being ableto measure both volatile(VOCs) and semi-volatile(SVOCs)compounds,capturing bioavailableconcentrations, and absorbingcompounds from air,water, and dermal contact. In Phase1 we demonstrated that the devicecan sequester selected chemicals over amonth-long period with precision (less than 20% variability) at multipletemperatures (-20to +30°C) and that thesechemicalscan then beextracted to providemeasurements ofexposure. In Phase2 we will: (1) demonstratechemicals that are sequestered can beexpanded to amore physicochemically diverseset ofcompounds, (2)extend to oneyear thetime period over which we test stability ofsequestration, (3) for thefirst time,calculate airconcentrations from wristband samplers usingspecially chosen performance referencecompounds (PRCs), and (4) develop packaging and labelingto support deployment of the wristbandsconformant to military specifications.