SYNBAL INC — Department of Health and Human Services SBIR Phase II: NCI
SYNBAL INC — SBIR Phase II award from Department of Health and Human Services.
- Amount
- $2,000,000
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- NCI
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
In this Fast track SBIR grant we aimby the end of Phase IIto prepare and commercialize a fully humanized rat with Knock out of many rat drug metabolism related CYPsinout Rat Drug Metabolism CYPModeland Knock in of the human counterpartIN PHASE I we will develop an Active GenesGene DriveAG GDrata rat with a properly configured Casto power Active GeneticsAGANDwe will prepare the first CYPKout KinCYP EAG GD is a new technology invented by Synbal s founders which allows Super Mendelian conversion to homozygositythusit can dramatically accelerate development of models with multiple genetic changesThese kinds of animals can be quickly crossedusing Active Genetics into immuno deficient or other rat strains useful in modeling oncology and other diseasesThusthis proposal answers the request for non mouse preclinical models to test therapeutics within animal models of diseaseIn Phase II we will prepare a fully humanized rat ready for sale to the pharmaceutical research communityAdditionallythe demonstration of Active Genetics in the ratis an entry point in other vertebrateslike dogspigs or monkeys and therefore it will have a huge implication on the future of toxicity and efficacy testing