TConneX Inc. — Department of Defense STTR Phase II: DHP16C-001
TConneX Inc. — STTR Phase II award from Department of Defense.
- Amount
- $499,999
- Agency
- Department of Defense · Defense Health Program
- Program / Phase
- STTR · Phase II
- Topic
- DHP16C-001
- Solicitation
- 16.C
- NAICS
- —
- Place of performance
- VA
- Period
- 2018-10-01 → 2021-02-23
Description
Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further be used to obtain various important parameters such as IC50, EC50, ED50,LD50, Km, Vmax,and AUC. The tool can be used for hormesis doseresponsecurves. In toxicology, hormesis isaspecial doseresponsefeaturecharacterized by low dose stimulation and high doseinhibition.Furthermore, thetool can model U-shaped doseresponserelationships frequently observed in toxicologyand epidemiology studies