BRIDGE 12 TECHNOLOGIES, INC. — Department of Health and Human Services SBIR Phase I: 400

Description

Project SummaryAbstract We propose to develop aT compact and portable hybrid magnet with high homogeneityandltppmandT of sweep rangeThe magnet system will be used in Overhauser Dynamic Nuclear Polarization experiments in the X Band for studying water dynamics in molecules and other analytical chemistry applicationsIn Phase Iwe will designbuild and test a prototype magnet to meet the above stated requirementsWe will characterize the magnet by measuring the field homogeneity using a three axis Hall probe as well as conducting control NMR measurements with a micro sample to prove that the system achieveppm homogeneity necessary to resolve the spectral lines of interest in an X band ODNP experimentIn a future Phase II project we will develop a compact ODNP spectrometer using this magnet and other subsystems that have proved to be commercially successful Narrative The proposed research focuses on the development of a compacthybrid magnet with high homogeneity for DNP NMR EPR spectroscopy in the X BandDNP enhances the inherently small signal intensities observed in a NMR experiment by up to two orders of magnitudedramatically increasing the overall sensitivity of the method and reducing the data acquisition timeThis is of high interest for NMR methods for pharmaceutical and analytical chemistry researchareas that are of significant interest to research funded by the U SNational Institutes of Health