ELECTRONIC BIOSCIENCES, INC. — Department of Health and Human Services SBIR Phase I: NCI
ELECTRONIC BIOSCIENCES, INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $299,999
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- NCI
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
During this Phase I SBIR project, Electronic BioSicences (EBS) will develop a direct, long-read, RNA strand sequencing methodology that is capable of sequencing both canonical and specific modified nucleotides with high-accuracy. This will result in the development of technology wherein a single-stranded RNA (ssRNA) molecule is translocated through a nanopore reader using an applied voltage bias and the sequence is directly read from the resulting translocation current signature. This methodology will be innovative relative to other nanopore-based approaches available in that no processive enzymes will be involved, yielding a new technology that is both long-read capable and high-accuracy, an accomplishment that is needed in the field of epitranscriptomics but not presently available. The resulting technology will be capable of providing a new and detailed understanding RNA and its regulation.