NANOCOMPOSIX, INC. — Department of Health and Human Services SBIR Phase I: NIAID
NANOCOMPOSIX, INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $225,000
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- NIAID
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
Onchocerciasis affectsmillion people worldwidepredominantly in sub Sahara Africaand is a major cause of irreversible blindness among adultswith serious socioeconomic consequencesThe proposal s objective is to develop a simple and inexpensive rapid diagnostic testRDTto detect the presence of two already identified onchocerciasis specific antigens from a finger stick blood sampleThe proposal combines three innovationsaNovel antigens currently provide asensitivity andspecificity when analyzed by ELISAThis is the first time that clinically relevant Ovolvulus antigens have been identifiedbGold nanoshells will be utilized as novel high contrast reporter particles to provide an ultra sensitive assaycA companion smartphone reader will quantify the amounts of antigens present in the sampleand capture GPS coordinates and a time stamp for real time spatial analysisContractor proposes to deliver a diagnostic via the following pursuitsAimSource key reagentsincluding antigensantibodiesand nanoparticlesAimIdentify optimal lateral flow assayLFAconfigurationAimDevelop two monoplexed LFAsone for each antigenand AimDeliver a biplexed LFAThe performance of the Phase I devicesensitivityspecificitywill be evaluated with overOnchocerca positive andOnchocerca negative preserved serum samples