Neurolux, Inc. — Department of Health and Human Services STTR Phase I: 105

Description

Project Summary NeuroLux Increcently developed and commercialized a fully implantablewireless optogeneticLED stimulator that istimes smaller by volume andtimes lighter in weight than current state of the art methodologywww neurolux org productsWith this technologythe neural circuitry of an unrestrictedfreely moving animal can be manipulated on demandallowing us to study the dynamic effects of neurostimulation on task performanceBased on this on going effortwe conceptualized a way to adapt the technology to permit wireless electroencephalographyEEGand electromyographyEMGrecordingsproviding a readout of the stimulation effects on neural and muscular activityExperimentallythe device will permit long termandgtyearcognitive and behavioral neuroscience studies that are outside the reach of current battery operated devicesmonthsExisting wireless recording systems require the implantation of largebulkyheavy power sources that often induce tissue necrosis and inflammationleading to experimental failure and precluding critical longer term studiesThe complexmulti part construction and the required batteries limit the manufacturability and the size weight operating time of current EEG systemsThe proposed program titledWireless Implantable Neural Recording Devicefocuses efforts on the development of a wirelessbattery free EEG EMG recordingsystem that will avoid bulky headpieces or other external hardware completelyrelying instead on a fully implantable architectureThis system will allow high quality real time electrophysiological data transmission streamswithout physical connection to external recording sources or power supply battery systemsThis type of systemwill undoubtedly greatly simplifying the equipment requirementscost and user interfaces for the investigatorCurrent collaborations with experts in neuroscience from Medical University of South CarolinaMUSCHarvard Medical and the US Army Research LaboratoryARLwe will allow rapid develop and validation of our novel EEG systemTesting the device using sleepseizure and social interaction models in three independent laboratories will ensure broad utility and allow for rapid circuit design modificationsLessons learned from this wireless data transfer effort will further allow us to adapt our technology into additional recording capabilities as future needs arise The Neural recording device proposed will be both compatible and complimentary with the current technology platforms offered by NeuroLux IncThis technology represents an important advance in tools for neuroscience research Project Narrative The proposed program focuses on the development of a battery freefully implantable device that permits wireless electroencephalographyEEGand electromyographyEMGrecordingswhile providing a real time readout of neural and muscular activity as animals behave naturally in home cagesin simple or complex environmentsas individuals or in socially interacting groupsThis system is fully compatible with the NeuroLux HF wireless electronic platform and control softwareThis novel technology represents an important advance in tools for neuroscience research