Oculogica Inc. — Department of Health and Human Services STTR Phase I: 102

Description

ABSTRACT This project will create the first objective measurement toolthe VisBoxfor the vision subtype of concussionVSCThis will enable physicians to identify VSC without an eye care professionalfor referral to a vision specialist for personalized vision therapy recommendationsThe persistence of concussion symptoms beyond several weeks is often a life altering situation for affected individualsand children are particularly vulnerable as they are at risk for co morbidities such as chronic painfatiguedepressionanxietyand learning difficultiesA lack of accessibleobjective vision diagnostics are critical barriers to identification of VSC and referral for treatmentThe VisBox will be a software product that is used with the OcuTrackerOculogica s proprietary eye tracking hardware platformThe VisBox will input eye movement measurements from the OcuTrackercalculate metrics that correspond to aspects of cranial nerve function affected during a concussionand use those metrics to calculate a score to predict VSC using an algorithm developed with guided machine learning in the course of this studyThe VisBox will be used by nonvision specialists to objectively measure three vision disorders related to concussionconvergence insufficiencyCIaccommodative insufficiencyAIand saccadic dysfunctionSDin underminutesduring the clinical visit where the concussion is diagnosedThe long term goal is to develop an objective assessment of vision characteristicsthat will enable physicians that are non specialists in vision toscreen for concussion related vision disordersidentify VSCmake decisions about the necessity of a referral for a comprehensive vision examinationmonitor the effectiveness of vision treatmentPhase I HypothesisVisBox can produce an output score that correlates with the presence or absence of TBIrelated vision disorderi eVSCby leveraging the OcuTracker visual stimulus and eye tracking systemSpecific Aim IGenerate OcuTracker eye tracking data and the diagnosis of TBI related vision disorder inpediatric concussion patientsSpecific Aim IIDevelop and validate VisBox algorithm for assessing CIAIand SD using OcuTracker dataPlans for Phase IIThe VisBox score will be used to predict responsiveness to vision therapy in a prospective randomized clinical studyPhase II will be a multi armed study comparing vision therapy with placebo therapy in concussion patients and assessing whether the VisBox software can predict which patients are responsive to vision therapyCommercial OpportunityVisBox customers are non eye care specialists including neurologistspediatriciansemergency room physicianssports medicine physiciansand concussion specialistsThe total addressable market is $MassumingM annual scans at $scan needed for concussions in the US