CHROMOLOGIC LLC — Department of Health and Human Services SBIR Phase I: NCI
CHROMOLOGIC LLC — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $299,980
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- NCI
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
Exosomes encapsulate and transport a wide variety of molecules generated by their cell of origin a process now thought to be a form of cellular signaling Exosome signaling is common across cell types and species but it is of particular interest in diseases with an inflammatory component While exosome isolation and analysis is useful to understanding the mechanisms behind these multifaceted diseases exosomes may also be exploited for their therapeutic potential In particular exosomes derived from healthy cells have been found to effectively alter the transcriptome of cancer cells Nonetheless there are no methods for differentiating between healthy and cancer cell derived exosomes in bodily fluids In this project we aim to develop a method for isolating exosomes and oncosomes coupled with a method for the differentiation of exosome populations