Dovetail Genomics, LLC — Department of Health and Human Services SBIR Phase II: 200
Dovetail Genomics, LLC — SBIR Phase II award from Department of Health and Human Services.
- Amount
- $1,709,035
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- 200
- Solicitation
- PAR14-088
- NAICS
- —
- Place of performance
- CA
- Period
- 2017-09-01 → 2019-08-31
Description
Project SummaryAbstractDovetailGenomicshasadaptedourinvitroproxityligationmethodforfecalmetagenomicsapplicationsWearedevelopingapowerfulandefficientapproachtodenovometagenomicsassembly that will allow the research and biomedical communities to move beyond single locusmolecule counting or statistical inferenceSuccessful development of this approach will provideasingleintegratedworkflowforaccurateassemblyofallmajorconstituentsofcomplexmetagenomicscommunitiesThistoolwillenableacomprehensiveunderstandingofthewaysour gut microbiome influences human health and diseaseInthisprojectDovetailGenomicswilldevelopthemodificationstothelaboratoryproceduresnecessary to efficiently capture and represent the diversity of microbes present in a human fecalsampleWewillalsomodifyanddevelopanewcomputationalapproachtometagenomicsassemblythatexploitstherichdatatypethatwegenerateThiscomputationalapproachwillachieve highly contiguous scaffolding and strain deconvolutionWe envision a robustfoolprooflaboratory protocol and software product that allows a clinician to generate a comprehensive viewof the dynamic human gut microbial environment from a small fecal sample in a manner of days