MODULATION THERAPEUTICS, INC. — Department of Health and Human Services SBIR Phase II: NCI
MODULATION THERAPEUTICS, INC. — SBIR Phase II award from Department of Health and Human Services.
- Amount
- $1,999,987
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- NCI
- NAICS
- —
- Place of performance
- WV
- Period
- —
Description
Melanocortin receptor MC R is highly expressed on uveal and cutaneous melanoma cells and not on any tissues that are of concern for causing toxicity We developed a proprietary ligand MC RL that binds to melanoma cells with high affinity and specificity Our recently completed SBIR Phase I contract results show no overt toxicity at dosages of Ac DOTA Ahx MC RL that produce outstanding efficacy against uveal and cutaneous melanoma in animal models Biodistribution radiodosimetry and PK studies also show rapid blood clearance with predominant distribution to the targeted tumor or to clearance organs with no organ specific pathology These results are very supportive of possible commercialization of a human drug candidate for the treatment of metastatic melanoma