NEURALYNX INC — Department of Health and Human Services STTR Phase I: 101

Description

Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain functions e g Kraskov et al Gelbard Sagiv et al There is accumulating evidence that the bandwidth used for clinical iEEG is inadequate and that high frequency oscillations can localize epileptogenic brain Gardner et al Bragin et al Urrestarazu et al Worrell et al These opportunities have not been fully exploited however due to limitations in data transmission and storage technologies that limit data acquisition directly by reducing the duration number of channels sampling rate or resolution of recordings in order to generate manageable amounts of data Performance of devices that acquire and store or transmit iEEG data would benefit significantly from efficient on board data compression We propose here to implement the Range Encoded Differences RED algorithm MEF REF an open source established compression strategy for electrophysiologic data on our Cube data acquisition device The Cube acquires up to channels of high bandwidth iEEG and transmits it via WiFi or stores it locally to an SD card The device has a powerful Zynq series Xilinx inc Field Programmable Gated Array FPGA running a Linux operating system Implementation of this data compression will reduce transmission and storage requirements to bits per sample in preliminary testing a doubling of itandapos s current capacity For Phase of this proposal we are focusing on implementation in existing hardware If successful it will represent a significant product improvement which could be made commercially available almost immediately Going forward however we hope to move the compression into an application specific integrated circuit ASIC to reduce power consumption in size in a phase application for this work Such an chip could have potential application in any device that acquired and stored or transmitted iEEG data such as next generation human implantable devices e g NeuroPace or Medtronic RC S or any continuously sampled time series data such as ECG The ASIC would be made commercially available independent of the Cube system High bandwidth neural data is becoming increasingly important in conducting neurophysiological research The work in this proposal is aimed at developing embedded compression of EEG on a state of the art wireless data acquisition system The successful completion of this project will lest substantially increase the data storage and transmission capacity of this system and be applicable to a multitude of systems in the future