SHIFA BIOMEDICAL CORPORATION — Department of Health and Human Services SBIR Phase II: NHLBI

Description

Project Summary AbstractThe epidemic of cardiovascular diseaseCVDis a global phenomenon that remains the number one cause of death throughout the worldkilling nearlymillion people per yeara number that is expected to grow tomillion byA high cholesterol level is well known risk factors for heart diseaseAlthough blood cholesterol can be lowered using a number of marketed drugsof which statins are the leading drugsonlyof patients taking these drugs are achieving the low density lipoprotein cholesterol goals set by the National Cholesterol Education ProgramNCEPFurthermorepatients with homozygous familial hypercholesterolemia who have markedly elevated cholesterol levels respond poorly to current drug therapyand are at very high risk of premature cardiovascular diseaseThese and other patients will dramatically benefit from an aggressive treatment of hypercholesterolemiaThe long term goal of this work is to develop novel orally bioavailable drugs for cholesterol loweringOur therapeutic target is the protease proprotein convertase subtilisin like kexin typePCSKPCSKcontrols the degradation of the LDL receptorLDLRin the liver and thereby contributes to cholesterol homeostasisPCSKis synthesized as a precursor protein that undergoes processingSecreted PCSKbinds to the LDL receptorLDLRand chaperones it to the degradation pathwayTo achieve our goalwe identified nanomolar orally active small molecule PCSKLDLR antagonists and demonstrated its efficacy in animal modelAs part of this Phase II proposalwe will undertake all the work required to characterize these compounds in multiple animal models for the proof of concept and conduct safety assessment in order to advance the lead compound toward IND enabling studies and clinical trials