Tatva Biosciences, LLC — Department of Health and Human Services SBIR Phase I: NCI

Description

Despite the recognition of obvious breast cancer BC racial health disparity we have failed to reduce the BC outcome gaps in African American women Unavailability of three dimensional D tissue culture model systems that mimics the original tumor s architecture and molecular characteristics of the racially disparate breast tumors limits our advancement in this area The overall goal of this SBIR Phase I proposal is to develop a standardized protocol for the establishment of a three dimensional D tissue culture model system using tumor mass from breast cancer patients of African American and Caucasian Americanracial ethnic background We will achieve overall goal in three parts A development of D tissue culture model system from racially disparate breast tumors B phenotypic characterization of the developed D model system to confirm their stability and C functional characterization and technical validation of the developed D tissue culture models Successful completion of this highly innovative proposal will result in a novel phenotypically stable D culture model system that will be a landmark in BC racial disparity research Moreover this will provide a strong foundation for our next step in that we will pursue a Phase II for developing up to D tissue culture model system for racially disparate BC of different molecular subtypes