Accacia International LLC — Department of Defense STTR Phase I: Marine mammals like bottlenose dolphins are maintained by US Navy's Marine Mammal Pro

Description

Marine mammals like bottlenose dolphins are maintained by US Navy's Marine Mammal Program to protect harbors and detect underwater mines. The maintenance and betterment of health of these dolphins in captivity is a priority in order to improve the fitness and readiness of these animals for defense missions. Accacia International proposes to develop probiotic pharmaceuticals to treat and prevent gastrointestinal diseases in dolphins. Preliminary results related to the indigenous commensal microbes, including potential probiotic strains obtained from our University research partner has enabled Accacia to get a headstart on the project. We will isolate candidate probiotic bacteria from the indigenous commensal bacteria present in dolphin fecal and oral samples and determine their antimicrobial activity against gastrointestinal (GI) pathogens. The immunomodulatory effects of the selected probiotic strain on cytokines like TNF and TGF-B will also be evaluated. The selected probiotics will be microencapsulated and freeze-dried to facilitate dosage and delivery. The viability of the microencapsulated probiotic bacteria during delivery and after release in simulated digestive tract conditions will be tested to ensure efficacy of the probiotic. In addition to US Navy, marine theme parks employing dolphins for recreational purposes will also benefit from the superior-quality probiotics developed by Accacia International.