Imbio, LLC — Department of Health and Human Services SBIR Phase II: NCI

Description

PROJECT SUMMARYIn this Phase II project Imbio proposes to analyze the National Lung Screening TrialNLSTdata to better characterize the relationship between Imbioandapos s quantitative measures of CT detected emphysema and health risks to inform the Comparative and Outcomes sections of the Imbio Smoking Cessation ReportReportdesigned in Phase Ito incorporate the Report effectively into a proven smoking cessation telephone counseling methodologyandto clinically validate the impact of the Report on high risk smokersandapossmoking behaviors in the context of a lung cancer screening programCigarette smoking is the leading preventable cause of premature disease and death in the United StatesCigarette smoking affects nearly every organ of the bodywith cigarette smokers more likely than nonsmokers to develop respiratory and pulmonary diseaseslung and other cancersand cardiovascular diseaseThe total economic cost due to tobacco in the U Sis over $billion a yearwhich includes at least $billion in direct medical careThe Report based on the Health Belief Modelincludes five sectionsImage Sectionvisual feedback and quantitative results based on the LDAComparative Sectionmapping of the patientandapos s lung status to a corresponding cohort of participantsHealth Outcomes Sectioninformation about the long term health outcomes for the associated participant cohortQuit Now sectionbenefits of making a quit attemptandOutreach sectioncontact information for smoking cessation supportLDA is a CT image processing application that quantifies the extent of tissue damage in patientsSpecificallyLDA is compatible with recommended lung cancer screening protocolsand offers a scalablecost effective solution for centers ranging from minimal to significant patient volumeA randomized controlled trial will be conducted to clinically validate the Reportandapos s impact onaLung screening participantsandaposmotivation to make a quit attempt by calling a Quitlineandbthe effectiveness of aminute telephone smoking cessation counseling session for motivating an actual quit attempt and abstinenceIt is hypothesized that incorporation of the Imbio Report into lung cancer screening can improve a patientandapos s readiness to quitmotivation to make a quit attemptand increase their use of a Smoking Cessation Quitline and or other smoking cessation resources including medicationsMore specificallyit is hypothesized that incorporation of the Imbio report into smoking cessation counseling can improve the effectiveness of the behavioral interventionThe Imbio Smoking Cessation Report will be the only smoking cessation product in the market providing truly personalized information and comparative detail PROJECT NARRATIVE The goal of this project is to create markers for health outcomes to refine the Imbio Smoking Cessation ReportReportdesigned in Phase Iestablish a telephone smoking cessation protocol incorporating the Reportand clinically validate the impact of the Report on smokers enrolled in a lung cancer screening programThe resulting Report will be the only smoking cessation product in the market providing truly personalized information and comparative detail