TRITON SYSTEMS, INC. — Department of Defense SBIR Phase I: AF141-005

Description

ABSTRACT: Continuous supply of oxygen to the tissue is essential for wound healing and resistance to infection. Oxygen provides the additional energy source for the repairing process. In the early stage of wound repair, fibroblasts start to migrate, divide, and produce collagen. To promote fibroblast proliferation and collagen synthesis, oxygen must be present in sufficient quantities. Angiogenesis in wounds is also affected by the oxygen level. Polymorphonuclear cells are one of the first lines of defense against bacteria in wound sites and produce superoxide, hydrogen peroxide, singlet oxygen, and other products via the respiratory burst to kill bacteria, and their function is directly dependent on oxygen tensions. Therefore, knowing tissue oxygenation accurately can improve wound healing and surgical outcome. Triton Systems, Inc. proposes to develop a transparent wound dressing and a monitoring device that provide real-time maps of tissue oxygenation. The proposed technology is non-invasive, repeatable, and simple to use and enables continuous long-term measurements. BENEFIT: The proposed wound dressing and monitoring device would improve the understanding of the role of oxygen in wound healing. Moreover, it can also be used to assess the wound oxygenation in response to different treatments, which can lead to better therapeutic regimens and better patient managements