ENDOMIMETICS LLC — Department of Health and Human Services SBIR Phase I: 105

Description

DESCRIPTION provided by applicant More than of the population has unruptured cerebral aneurysms approximately million people in the US About rupture per year with devastating consequences More than of patients with ruptured aneurysms die and of who survive have significant disabilities Detachable microcoils are now used in more than of treated aneurysms The risk of recurrence or recanalization remains surprisingly high at approximately Various modifications are used clinically with limited evidence that they provide improvement over bare coils An important factor to improve clinical efficacy of the coils is to enhance endothelization leading to durable occlusion We have developed a nanomatrix coating that mimics the characteristic properties of native endothelium Thus we hypothesize that the nanomatrix coating on the coil can enhance healing thereby promoting durable closure of aneurysms The coating provides sustained release of nitric oxide NO over months thus recruiting and retaining endothelial cells and endothelial progenitor cells It also incorporates an endothelial cell adhesive ligand that promotes endothelial cell retention and migration The bionanomatrix is a biocompatable peptide based material and is coated on the coils by simple water evaporation This coating method minimizes the risk of inflammatory responses In this Phase I SBIR we propose to evaluate and optimize the coating for platinum coils for treatment of brain aneurysms This will include optimizing the coating method for this specific device evaluating physical characteristics of the coating and assessing effects on endothelial and smooth muscle cell growth In collaboration with Dr Kadirvelandapos s group at the Mayo Clinic the efficacy of this coating will be evaluated in an established rabbit model of aneurysms compared with bare platinum coils Development of the nanomatrix coating that enhances occlusion of aneurysms and healing over the microcoils may have significant impact in the treatment of patients with brain aneurysms With successful completion of Phase I we plan to move forward in Phase II towards IDE submission PUBLIC HEALTH RELEVANCE Brain aneurysms carry the devastating risk of rupture leading to death or permanent disability Currently available platinum coils used to treat aneurysms are limited by a high rate of recurrence Endomimetics LLC has developed a novel nanomatrix which when coated onto coils could enhance endothelialization and reduce the risk of brain aneurysm recurrence