LYNNTECH INC. — Department of Defense SBIR Phase II: DHP13-013

Description

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or limited analysis capabilities these systems do not function effectively as point-of-care (POC) instruments. In Phase I Lynntech developed a novel, rapid test cartridge to measure an individual platelet receptor contribution to platelet coagulation in whole blood through an electrochemical-fluidics system. As part of a follow-on effort in Phase II, Lynntech proposes to expand the test cartridge to simultaneously analyze multiple platelet receptor contributions to platelet coagulation. The system automation will be designed such that a single, small blood sample will be fully analyzed within a disposable cartridge to minimize user effort and error.