SELFA, INC. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbid
SELFA, INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $212,718
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- HL14-011
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In United States and Europe alone, about 15 million patients are annually admitted to emergency departments with acute coronary syndrome.These patients are immediately screened for potential acute myocardial infarction (AMI) via electrocardiogram and biomarker detection in blood samples. Due to its high specificity and elevated concentrations in blood for hours past an incident, cardiac troponin I (cTnI) has become one of the most reliable biomarkers for diagnosing AMI where a cTnI concentration of less than 0.10 ng/mL is considered a negative result, while a cTnI concentration of 0.10 ng/mL or greater is considered a positive result. Furthermore, recent studies have shown that cTnI could also be used for AMI risk stratification. However, for this intended use, ultra-sensitive assays are required to detect slightly elevated levels of cTnI in blood samples. Currently there are