Angion Biomedica Corp. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): Chronic Pancreatitis (CP) is characterized by continu
Angion Biomedica Corp. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $224,347
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-234
- NAICS
- —
- Place of performance
- NY
- Period
- —
Description
DESCRIPTION (provided by applicant): Chronic Pancreatitis (CP) is characterized by continuous or recurrent inflammation of the pancreas that leads to permanent destruction of the pancreas resulting in exocrine and endocrine insufficiency. CP is a common disorder associated with significant morbidity and mortality with an incidence of 8.2 and a prevalence of 27.4 per 100 000 population. The etiology of CP is complex and about 70% of cases are due to excessive alcohol consumption. Alcoholic chronic pancreatitis is one of the more painful and serious consequences of alcohol, and the role of alcohol as a predisposing factor in severe pancreatitis is underappreciated. The most critical step for development of chronic pancreatitis is activation of pancreatic stellate cells (PSCs) and increased extracellular matrix (ECM) deposition that leads to fibrosis. Several growth factors, cytokines and alcohol can induce PSCs activation. Pancreatic fibrosis is a constant histopathological feature of chronic pancreatitis