BIOCREDE INC. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): We propose a completely new, low cost and robust bact
BIOCREDE INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $199,908
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-050
- NAICS
- —
- Place of performance
- MI
- Period
- —
Description
DESCRIPTION (provided by applicant): We propose a completely new, low cost and robust bactericidal urinary 100% silicone Foley catheter with a gt3-6 month shelf-life, that will utilize electromodulated delivery of nitric oxide (NO) for up to 45-60 d to serve as a potent antimicrobial/antibiofilm agent. The first generation device will possess a stable inorganic nitrit salt reservoir within on lumen, in which the nitrite can be converted electrochemically (at surface of microwire) to NO via a simple Cu(II)-ligand redox mediator. The NO released quickly diffuses out of the silicone walls onto the urine collection lumen and the catheter's outer surface to prevent/disrupt biofilm formation that will eliminate catheter-associated urinary tract infections (CAUTI). The special, ISO13485 compliant, 20Fr triple-lumen 100% silicone Foley catheter has been manufactured via an OEM company, and its unique third lumen will be employed by Biocrede Inc to contain and seal off the NO releasing formulation that is electro