BIODISCOVERY, INC — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): Cancers selected for the NIH's The Cancer Genome
BIODISCOVERY, INC — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $156,809
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-234
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
DESCRIPTION (provided by applicant): Cancers selected for the NIH's The Cancer Genome Atlas (TCGA) project have been chosen because of their poor prognosis and overall public health impact. Select tissue samples have been profiled for gene and miRNA expression, promoter methylation, DNA sequence and mutation analysis, as well as copy number variation (CNV), with total expenditures of 275 Million13. The copy number variation (CNV) information, derived from the raw array-based comparative genomic hybridization (aCGH) and SNP-array data, has been successfully utilized in specific application areas, such as identification of significant recurrent aberrations in each tumor type from population-wide, tumor- specific analysis. However, the full potential of this data has not yet been exploited. The two major obstacles have been the method used to perform the initial data processing which have somewhat limited its utility, and the lack of a comprehensive integrated data access and analytical platform for copy n