BRIDGE 12 TECHNOLOGIES, INC. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): The proposed research focuses on the development DNP-
BRIDGE 12 TECHNOLOGIES, INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $205,508
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-234
- NAICS
- —
- Place of performance
- MA
- Period
- —
Description
DESCRIPTION (provided by applicant): The proposed research focuses on the development DNP-enhanced high-resolution magic-angle-spinning (HRMAS) magnetic resonance spectroscopy (MRS) to quantify cellular metabolities within intact prostate tissue. This willallow the study of micro-dissected pure pathological features, which is currently not possible due to the sensitivity limitations of the method. With DNP, the inherently small signal intensities in an NMR/MRS experiment can be drastically enhanced. In recent years, DNP has proven to be a robust method to increase signal intensities in NMR experiments in laboratories around the world and substantial progress has been made in adapting DNP for solution-state NMR spectroscopy. The enhancements available through DNP (gt 80) are in Iarge contrast to the sensitivity gain that can be expected from a cryo-probe. However, since (human) tissue has the characteristics corresponding of solid and solution-state NMR samples, specific technology has to be developed to