FOX CHASE CHEMICAL DIVERSITY CENTER INC. — Department of Health and Human Services SBIR Phase II: DESCRIPTION (provided by applicant): Systemic fungal infections are increasingly common, e

Description

DESCRIPTION (provided by applicant): Systemic fungal infections are increasingly common, especially in immune compromised patients. While new antifungal drugs have been developed, there is still a high mortality associated with these infections, especiallythose due to Candida albicans, other non-albicans species (NAS). This is due to the limited spectrum of the drugs, significant side effects, as well as the development of resistance, leading to an increase in drug-resistant strains. Host defense proteins(HDPs) are naturally occurring, broad-spectrum antimicrobial agents that have been examined recently for their utility as therapeutic antibiotics and antifungals. Chief among their strengths is that microbes do not generally develop resistance to these agents. Unfortunately, they are expensive to produce and are often sensitive to protease digestion. We have demonstrated the potent activity of a series of inexpensive non-peptidic oligomers and compounds that mimic HDPs in both structure and activity against