Luminomics Inc. — Department of Health and Human Services STTR Phase I: DESCRIPTION (provided by applicant): Our goal is to create a compact, affordable, fully au
Luminomics Inc. — STTR Phase I award from Department of Health and Human Services.
- Amount
- $225,000
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- STTR · Phase I
- Solicitation
- PA13-235
- NAICS
- —
- Place of performance
- GA
- Period
- —
Description
DESCRIPTION (provided by applicant): Our goal is to create a compact, affordable, fully automated, screening system for large-scale drug 2 testing in living small animal disease models (e.g., worms, flies, and fish). Modern drug discovery is 3 driven by high-throughput screening (HTS) systems that have the capacity to evaluate large chemical 4 compound 'libraries'. The majority of hits identified by in vitro HTS assays fail at animal testing stages 5 after significant investments in time and costs have already been made. This increase drug 6 development costs and presents a critical barrier to the discovery of novel therapies. A solution to this 7 problem is to integrate small animal disease models into HTS platforms at the earliest stage of the 8 discovery process. Powerful 'high-content' in vivo screening systems use automated imaging 9 processes to collect phenotypic data following drug exposures. However, these methods cannot attain 10 true HTS capacities and therefore cannot fully address current