PHYSICAL SCIENCES INC. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): The goal of the proposed SBIR program is to develop l

Description

DESCRIPTION (provided by applicant): The goal of the proposed SBIR program is to develop lyophilizer manufacturing hardware and processing procedures that enable the efficient freeze drying of pharmaceutical product formulations in prefilled syringes. Theuse of prefilled syringes 1) reduces dosing and medication errors, 2) reduces the risk of microbial contamination, 3) improves dosing accuracy, 4) reduces waste by eliminating the need for vial overfill, 5) increases convenience and reduces the time required for emergency use and 6) improves the ease of administration for the healthcare profession and patient. Unfortunately, very few lyophilized drugs are provided in prefilled syringes due, in part, to the challenges associated with producing high quality freeze dried drug product in single or dual chamber syringes. The difficulty of freeze drying in prefilled syringes is primarily due to the poor heat transfer betwee the temperature controlled dryer shelves and the syringes due to the odd shape of the