RADIATION MONITORING DEVICES, INC. — Department of Health and Human Services SBIR Phase II: NHLBI

Description

DESCRIPTION provided by applicant Hemorrhagic shock is a major cause of death in emergency departments and trauma centers Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs The long term goal of this proposal a collaboration between Radiation Monitoring Devices and the Mayo Clinic is to develop a sensor patch CBFM that attaches to a patientandapos s skin and continuously monitors capillary blood flow and predicts the onset of hemorrhagic shock The sensor is based upon diffuse correlation spectroscopy DCS DCS measures fluctuations in near infrared light scattering of blood cell motion in capillaries DCS extracts th characteristic time constants due to mean blood flow velocity The aims of the proposal are Integrate DCS system with physiological monitors Perform definitive measurements using the human lower body negative pressure LBNP model for hemorrhage Analyze DCS and physiological data and answer the following questions Is normalization of subject to subject variation possible Is subject to subject variability reduced by DRS based determination of tissue scattering and absorbance properties Is predictive value improved by addition of vital parameters and if so what is the andquot bestandquot approach to multiparametric andquot smartandquot algorithms Is predictive value improved by measuring the change in with progressive bleed Perform LBNP studies under the US Army LBNP pressure to failure presyncope protocol Test the CBFM in a clinical setting during high blood loss human spinal surgery Complete all reportsPUBLIC HEALTH RELEVANCE The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs The goal of this proposal is to develop a sensor patch that attaches to a patientandapos s skin and continuously monitors capillary blood flow and in conjunction with other monitors predicts the onset of hemorrhagic shock