SILBIOTECH, INC. — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): This Phase I research proposal is to investigate the
SILBIOTECH, INC. — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $224,931
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-234
- NAICS
- —
- Place of performance
- MD
- Period
- —
Description
DESCRIPTION (provided by applicant): This Phase I research proposal is to investigate the feasibility of developing a novel Biomarker Breast PapTest for screening Nipple Aspirate Fluid (NAF) and detecting breast cancers at the tumor-in-formation stage before mammographically detectable tumors are developed. Although there is a slight decline in deaths from breast cancer in recent years, it continues to be the most diagnosed cancer and the second leading cause of cancer deaths for women in the USA. We canexpect a drastic reduction in the incidence and deaths if high risk women are identified before tumor formation and treated prophylactically. However, precise identification of high risk women for prophylactic measures has been a major clinical challenge.Currently, risk is assessed by Gail scoring and cytological examination of ductal cells in NAF elicited using NeOMatrix instrument (HALO Breast Pap Test). However, numerous studies have shown that cytology based risk assessment is highly subjective an