Soligenix, Inc — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): This proposal describes development of an immunomodul
Soligenix, Inc — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $300,000
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Solicitation
- PA13-234
- NAICS
- —
- Place of performance
- NJ
- Period
- —
Description
DESCRIPTION (provided by applicant): This proposal describes development of an immunomodulatory peptide that targets the host defense system for treatment of acute pneumonic melioidosis. The disease is caused by Burkholderia pseudomallei (Bps), a non-spore-forming motile saprophytic bacterium that can be transmitted from the soil to humans by inhalation, through cuts in the skin and by ingestion. Bps is classified as a category B biological threat agent by U.S. Department of Health and Human Services (DHHS) and in the 2012 Health Emergency Medical Countermeasure Enterprise (PHEMCE) Strategy document because of its infectivity by the aerosol route and environmental robustness. Furthermore, Bps is endemic in Southeast Asia, Brazil, Africa, the Middle East, and Northern Australia. Bps is intrinsically resistant to antibiotics normally used for first line treatment of Gram-negative septicemia, accounting for high mortality in endemic regions. Preventative or therapeutic vaccinations are not yet available, i