Theranova LLC — Department of Health and Human Services SBIR Phase I: DESCRIPTION (provided by applicant): Pediatric sepsis is one of the leading causes of chil

Description

DESCRIPTION (provided by applicant): Pediatric sepsis is one of the leading causes of childhood mortality, responsible for over half a million deaths world-wide. A key goal in treating children suffering from septic shock is to normalize cardiac function while maintaining optimal fluid balance and tissue oxygenation levels. Intravenous fluid resuscitation and management is often critical to survival, but can also lead to fluid overload and potentially fatal downstream consequences. Currently there is a lackof adequate tools with which to monitor patient responses to fluid infusion, particularly those that can safely and accurately measure cardiac output or detect the onset of fluid overload. In response to this need we have developed the PediaSense catheter? Its innovative design combines fast pressure sensing functionality within the structure of a standard 8F pediatric urinary drainage catheter. The sensitivity and frequency of our pressure measurement enables the monitoring of changes in cardiac outp