SPATIAL GENOMICS, INC. — Department of Health and Human Services SBIR Phase II: NIA
SPATIAL GENOMICS, INC. — SBIR Phase II award from Department of Health and Human Services.
- Amount
- $1,229,313
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- NIA
- Solicitation
- PAS22-196
- NAICS
- —
- Place of performance
- CA
- Period
- 2023-09-21 → 2025-05-31
Description
SUMMARY The major goal of this project is to study human Alzheimer’s Disease (AD) brains using the Spatial Genomics GenePS instrument for automated large scale gene expression analysis at single cell resolution. At Spatial Genomics, we are commercializing the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to be imaged directly in brain samples. We have experience working with human brains with our seqFISH technology and will hone the technology for use in human brains. Using the seqFISH method, we will identify changes in cell types, spatial organization of groups of cells, and signaling interactions between neighboring cells in the human AD brain.