PARABON NANOLABS, INC. — Department of Defense SBIR Phase I: A development program is proposed for a design automation software package that enables th
PARABON NANOLABS, INC. — SBIR Phase I award from Department of Defense.
- Amount
- $150,000
- Agency
- Department of Defense · Office for Chemical and Biological Defense
- Program / Phase
- SBIR · Phase I
- Solicitation
- 2012.2
- NAICS
- —
- Place of performance
- VA
- Period
- 2012-12-06 → 2013-12-14
Description
A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon existing software for DNA origami design, this project will result in software able to optimize DNA staples and other origami modifications to achieve target charge and hydration force distributions. The objects to be generated with this software will be able to mimic any of the many surface/surface interactions found in biological or technological applications. Such design software will significantly expand the capabilities of users to produce systems that are capable of highly specific interactions with target macromolecular species.