UES INC — Department of Defense SBIR Phase II: Detection of biological warfare agents in a real-world setting is an increasingly urgent p

Description

Detection of biological warfare agents in a real-world setting is an increasingly urgent problem. Many of the current state-of-the-art sensors require large biomolecules, such as antibodies, to achieve binding of the target molecule and subsequent reporting of the binding event. This type of detection is not stable under deployed environmental conditions and often requires blocking and washing steps. These technical hurdles are a drawback when considering use of these technologies in a battlefield situation. Here, we propose a sensor that is based on stable biomolecules that act as ligands for the target(s) of interest. Due to their small size, these ligands are not susceptible to conformational instability and the sensors should have a long lifetime even when deployed. Additionally, the sensor incorporates an exponential amplification of the output signal when the target of interest binds, effectively eliminating the background and false positive results.