MOLECULAR EXPRESS, INC — Department of Health and Human Services SBIR Phase I: 77
MOLECULAR EXPRESS, INC — SBIR Phase I award from Department of Health and Human Services.
- Amount
- $299,993
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- 77
- NAICS
- —
- Place of performance
- CA
- Period
- —
Description
Th is proposal aim to develop a VesiVax® platform-based liposomal formulation that will efficiently display the HIV immunogen, HIV Env gp120 (A244) antigen, and elicit a potent neutralizing antibody response. The HIV Env(A244) antigen will be prepared as HIV-Env(A244)-Cys or HIV-Env(A244gp41e)-HD. The purified antigens will be formulated with VesiVax® liposomes containing the approved Toll-like Receptor 4 agaonist monophosphoryl lipid A. These VesiVax® HIV-Env(A244) immunogen liposome formulations will be tested in mice to identify the formulation that can stimulate the strongest anti-HIV-Env(A244) response