POSIT SCIENCE CORP — Department of Health and Human Services SBIR Phase I: NIA

Description

DESCRIPTION provided by applicant The goal of the current Phase I project is to develop to clinical trial readiness and evaluate feasibility of a computerized cognitive training program Tonic and Phasic Alertness Training TAPAT to treat insomnia in older adults As a group individuals with age related sleep quality decline tend to have poorer long term prognosis as indicated by negatively impacted quality of life and increased risk of cardiovascular decline depression substance abuse and mortality Our preliminary data is among the first evidence to demonstrate that TAPAT targeting sustained attention and cognitive control can improve regulation of sleep resulting in increased total sleep time and sleep quality At the completion o this project we will have outcomes data sufficient to support a large scale randomized controlled trial in Phase II medical device trial designed to establish medical claims defining the efficacy of this intervention to treat age related chronic insomnia At the completion of Phase II we expect to have sufficient data for submission to the FDA for clearance as a medical device indicated for sleep enhancement in chronic late life insomnia PUBLIC HEALTH RELEVANCE The goal of this project is to further develop to pivotal trial readiness and evaluate a computerized cognitive training program Tonic and Phasic Alertness Training TAPAT designed for the treatment if insomnia in older adults This intervention may benefit a large population of older adults that suffer from poor sleep and lack of long term viable treatment options