BIOLOGICAL MIMETICS, INC. — Department of Defense STTR Phase II: DTRA14B-002
BIOLOGICAL MIMETICS, INC. — STTR Phase II award from Department of Defense.
Phase II STTR prototype / development signal
- Phase II is where Department of Defense funds deeper R&D after feasibility. Incumbents with Phase II history are serious competitors on adjacent topics.
- Use this award as past-performance context and to map customer organizations for STRATFI/TACFI-style transition planning.
- Obligated amount $990,021 is consistent with substantial Phase II-scale effort; compare to related awards from the same agency.
- Topic code DTRA14B-002 links this award to a solicitation family — search the same topic stem for incumbents and recompete timing.
- Amount
- $990,021
- Agency
- Department of Defense · Defense Threat Reduction Agency
- Program / Phase
- STTR · Phase II
- Topic
- DTRA14B-002
- Solicitation
- 14.B
- NAICS
- —
- Place of performance
- MD
- Period
- 2017-06-22 → 2019-06-25
Description
The discovery and commercial development of licensed vaccines often take many years of research followed by years of pre-clinical and clinical development. We propose to assess the feasibility of using a novel irradiation-inactivation technology to develop vaccines more rapidly. The technology utilizes a manganese-peptide complex to protect antigenic proteins from ionizing radiation while allowing the nucleic acid genome to be destroyed. In the Phase I, we demonstrated the feasibility of the method using poliovirus (PV1-Sabin). All objectives of the Phase I were met or exceeded. In the Phase II, we propose to continue the development of an improved trivalent inactivated polio vaccine and test the technology against a bacterial target. The improvements to the polio vaccine include (1) the use of attenuated Sabin strains to improve biosafety profiles and (2) a reduced cost due to improved immunogenicity as compared to existing chemically-inactivated vaccines (IPV). At each stage of development, the improved vaccine candidate will be tested for stimulation of neutralizing antibodies in the accepted animal model. We also propose to expand the study to include the antibiotic-resistant bacteria, Acinetobacter baumannii, using mouse models of lung and wound infection.