AGAVE BIOSYSTEMS INC. — Department of Defense SBIR Phase I: Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT)
AGAVE BIOSYSTEMS INC. — SBIR Phase I award from Department of Defense.
- Amount
- $100,000
- Agency
- Department of Defense · Defense Advanced Research Projects Agency
- Program / Phase
- SBIR · Phase I
- Solicitation
- 2012.1
- NAICS
- —
- Place of performance
- NY
- Period
- 2012-07-19 → 2013-07-31
Description
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.