APPLIED GEOSOLUTIONS LLC — Department of Health and Human Services SBIR Phase II: R

Description

Specific Aim #1: Operationalize spatio-temporal CyanoHAB exposure epoch metrics• Fuse multi-scale and disparate satellite remote sensing platforms and automate retrievals overspace and time to derive CyanoHAB exposure metrics. We will build enterprise software to fullyautomate the harmonization and fusion of NASA’s Landsat-8 OLI and ESA’s Sentinel-2 andSentinel-3 satellite platforms to provide long-term (1984-present) moderate spatial resolution(30meter pixels) and high temporal frequency CyanoHAB exposure metrics (CyanobacteriaIntensity, Color Dissolved Organic Matter, Total Suspended Solids, Floating Algae Index,Chlorophyll-a Concentration, andamp; toxins). The decision support tool automates epoch synthesis tounderstand incubation periods and exposure triggers for neurodegenerative diseases. Specific Aim #2: Scale on-demand CHABMAP commercial product services• Scale and implement CHABMAP data services for infinite scalability using BigData cloudtechnologies. This Aim involves three main development efforts: adapting our proprietaryGeospatial Image and Processing System (GIPS) capabilities to an AWS-deployable auto-scalingcluster, creation of user interfaces and application programming interfaces (APIs) to interact withthese services, and enhancements to the base GIPS framework to facilitate intercommunicationbetween remote GIPS-enabled archives and the cloud processing streams. This includes thecreation of deployable compute instances, optimization of computation and parallelizationspecific to AWS deployment, optimization of temporary and long-term storage of intermediateproducts, and optimization of communication and data transfer with end users. Ultimately, thisAim will allow for the assessment and monitoring of CyanoHAB conditions for any waterbody orregion (i.e., North America) on the planet. Specific Aim #3: Execute risk assessment frameworks with public health partners• We will work in partnership with Cleveland Clinic, Dartmouth Hitchcock Medical Center,University of Miami, Macquarie University, NIH’s Neuromuscular Diseases Research Section andCDC’s Agency for Toxic Substances and Disease Registry (National ALS Registry) to assess the roleof CyanoHABs exposure as a risk factor for Amyotrophic lateral sclerosis (ALS) using patients,clinic-, and population-based controls across diverse settings and geographies. Each applicationend user has ongoing risk assessment frameworks (i.e., Gene-Environment, Residential HistoryMachine Learning, eco-epidemiological, molecular biology) which our CHABMAP technology willintegrate exposure epoch metrics to understand the etiology or ALS and support drug discovery. Proposed Innovation CHABMAP technology automates the quantification of toxic Cyanobacterial Harmful Algal Bloom (CHAB) exposure epochs for any waterbody or catchment in the world for the past four decades using multi-scale harmonized satellites. We use custom and proprietary techniques combined with BigData software to generate historical exposure (“exposome”) profiles as well provide Decision Support Tools services for CHAB monitoring in near-real time. During Phase 2 and beyond we work with world experts to integrate our commercial products and services into neurodegenerative disease Gene-Environment (GxE) risk assessment frameworks. Proposed Products, Services, Outcomes• Develop historical CHAB exposure measurements working with environmental agency partners• Assessment of CyanoHABs as a risk factor for ALS across multiple, independent study regions• CHABMAP on-demand Analytics-as-a-Service platform operating at end of Phase 2• Support discovery of etiology and drug development for neurological disorders and diseasesProject Narrative Design, build, and operate a cloud-based Cyanobacterial Harmful Algal Bloom Mapping and Analysis Platform (CHAB-MAP) for developing public health applications’ in partnership with NASA, EPA, and medical centers. Assess as risk factor for ALS. Help address cyanobacteria and toxicity public help threats.