BIOMEDICAL DEVELOPMENT CORP — Department of Health and Human Services SBIR Phase I: 104

Description

Opioid abuse has become an epidemic with devastating healthsocialand economic consequences for the United StatesDrug overdose deaths have nearly tripled fromDuringdrug overdoses accounted forU Sdeathsincludingthat involved an opioidopioid pain relievers and heroinOpioid analgesic overdose is now the leading cause of injury death in the U Sinthere were approximately one and a half times more drug overdose deaths than deaths from motor vehicle accidentsTreatment for an opioid use disorderOUDis a complex multifactorial process often involving medication assisted treatmentMATand requiring changes in deeply imbedded behaviorsPatients are treated in the clinicbut fight addiction in their daily livesRates of relapse are highand access to supportive care is limited and costlyTreatment approaches must be tailored to address each patient s drug use patterns and drugrelated medicalpsychiatricand social problemsWhile a few online tools exist to assist patients in their recoverycurrent products offer only generalized information that may or may not be relevant and timelyor act solely as supportive social networking servicesIn previous workwe developed KIOSan innovative software platform derived from nonlinear control theoryKIOS tracks multiple interacting symptoms to map patient trajectories and deliver evidence based intervention strategies responsive to the specific needs of individualsAccessible via computer or mobile devicesKIOS provides patients real time advice and reinforcement of lifestyle interventions to improve selfmanagementKIOS also can provide between visit reporting to clinicians via downloadable reports or direct online monitoringThereforethe goal of this project is to adapt KIOS to patients with an opioid use disorderThe development of this innovative tool to help patients manage OUD has the potential to have a profound impact on public health and achieve significant commercial successThis Phase I SBIR study has two Specific AimsSpecific AimIdentify Patient Trajectories of OUD and Link Expert Advice to Changing Patient States Specific AimBuild User Interfaces and Test Feasibility in Patients with OUDThe U Sis in the midst of an unprecedented opioid epidemicwith devastating socialeconomic and health consequencesThe societal cost of opioid abuse is estimated to be $billion annuallywhich includes lost productivitycriminal justice costsand medical costsReal time delivery of intervention strategies responsive to patientsspecific needs would improve outcomesreduce healthcare costsand have a significant impact on public health