VENATORX PHARMACEUTICALS INC — Department of Health and Human Services SBIR Phase II: NIAID
VENATORX PHARMACEUTICALS INC — SBIR Phase II award from Department of Health and Human Services.
Phase II SBIR prototype / development signal
- Phase II is where Department of Health and Human Services funds deeper R&D after feasibility. Incumbents with Phase II history are serious competitors on adjacent topics.
- Use this award as past-performance context and to map customer organizations for STRATFI/TACFI-style transition planning.
- At $3,000,000, this is a large obligation for typical SBIR Phase sizing — worth reviewing for scope breadth and teaming opportunity.
- Topic code NIAID links this award to a solicitation family — search the same topic stem for incumbents and recompete timing.
- Amount
- $3,000,000
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase II
- Topic
- NIAID
- Solicitation
- PA16-302
- NAICS
- —
- Place of performance
- PA
- Period
- 2017-08-07 → 2020-07-31
Description
Project Summary Abstractlactam antibiotics are the most widely used antibiotic class in the U Saccounting for more thanof antibacterial prescriptionsAmong other rolesthey are critical therapeutics for difficult to treat infections due to gram negative pathogens such as EcoliKlebsiella pneumoniaeand Enterobacter sppHoweverthe utility of this class of antibiotics is being rapidly compromised by the alarming spread of newlactamase resistance mechanismsenzymes produced by bacteria that hydrolytically inactivatelactam antibioticsA particularly important concern is the lack of orally bioavailablelactamlactamase inhibitorBLIcombinations capable of addressing this emerging challengeboth in the Biodefense arena and in the hospital community settingsOrally availablelactam combinations with legacy BLIse gamoxicillin clavulanic acid or Augmentindemonstrate reasonable activity against Gram negative pathogens expressing Ambler Class A Extended Spectrum Beta LactamasesESBLsbut lack activity against organisms expressing Class A carbapenemasesKPC typeClass C cephalosporinaseschromosomal and plasmidicand Class D oxacillinasesWe have identified a compound series with potent and broad spectrum activity against these serinelactamasesThese compounds rescue the activity of the orally bioavailable cephalosporin cefixime in MDR strains of Gram negative Enterobacteriaceaeincluding Ecoliand KpneumoniaeMoreoverwe have shown that prototype prodrugs in the series demonstrate striking oral bioavailability in rodentsand that they rescue cefixime activity in murine models of bacterial diseaseThe objectives of this project are to advance the selected Development Candidate to IND filing for use in combination with cefixime Project narrative This application focuses on development of the first oral product able to address the alarming emergence oflactamase expressinghighly resistant NIAID Category C pathogensThe product will be composed of a novelbroad spectrumorally bioavailablelactamase inhibitor plus a known orally bioavailable cephalosporin