ABBRATECH INC. — Department of Health and Human Services SBIR Phase I: 400
ABBRATECH INC. — SBIR Phase I award from Department of Health and Human Services.
Phase I SBIR feasibility signal
- Phase I awards fund proof-of-concept work. For capture teams, they mark early interest from Department of Health and Human Services in a technical approach.
- Watch for Phase II follow-ons from the same firm/topic family — that conversion path is where budgets and transition pressure rise.
- Obligated amount $339,150. Cross-check similar awards in the same agency and technology tags for going-rate context.
- Topic code 400 links this award to a solicitation family — search the same topic stem for incumbents and recompete timing.
- Amount
- $339,150
- Agency
- Department of Health and Human Services · National Institutes of Health
- Program / Phase
- SBIR · Phase I
- Topic
- 400
- Solicitation
- PA21-259
- NAICS
- —
- Place of performance
- CT
- Period
- 2022-04-01 → 2023-03-31
Description
ABSTRACT The poor reproducibility of published research is a major focus of the scientific community in recent years. Western analysis Abs are often validated against antigen (Ag) materials such as mammalian cell lysates which have undergone treatment (e.g., chemical exposure, UV radiation etc.) to induce (or reduce) modification of residues on a protein of interest. Several stages during the generation of this material can pose challenges. First, it can be difficult to identify the appropriate treatment and cell line for the residue of interest. Second, treated cell lysates can be technically challenging to generate reproducibly. Even with careful adherence to a protocol, these lysates may have varying degrees of modification present in “treated” and “untreated” samples. This can lead to incorrect specificity determination for the Ab. A reliable method for validating PTM-specific Abs would be one where each Ag sample contains the target sequence residue with either 100% modification or 100% non-modification. We have developed a system that provides that certainty.