SBIR/STTR Topic Briefs

Every open topic gets a structured capture brief — playbook, pWin cues, related awards, and peer topics — matched to AFWERX open topics, STTR, Direct-to-Phase II, pre-release, or traditional agency SBIR.

Monthly open-topic digest · Live opportunities · AFWERX open topics · Open SBIR topics hub

Brief types

• Pre-release topic brief (pre_release)
• STTR research-partner brief (sttr)
• Direct-to-Phase II brief (direct_to_phase_ii)
• AFWERX / SpaceWERX open-topic brief (afwerx_open)
• Agency SBIR topic brief (agency_topic)

Open topics with briefs

• SAFER CHEMICALS
  Agency SBIR topic brief · EPA · SBIR · Closes 2026-11-08
• CIRCULAR ECONOMY/SUSTAINABLE MATERIALS
  Agency SBIR topic brief · EPA · SBIR · Closes 2026-11-08
• AIR QUALITY
  Agency SBIR topic brief · EPA · SBIR · Closes 2026-11-08
• CLEAN AND SAFE WATER
  Agency SBIR topic brief · EPA · SBIR · Closes 2026-11-08
• High Speed, Low Temperature Hyperspectral Imager for High Enthalpy Ground Testing
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Cyber Resiliency for Fog and Edge Computing Devices
  Pre-release topic brief · USAF · STTR · Closes 2026-11-25
• ONR Open Topic for Low-Cost Heads Up Displays (HUDs) for Virtual & Augmented Reality (VR/AR)
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• Advanced Reserve Power Source Technologies
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Low SWaP, 2-micron Fiber Amplifiers
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• US Production of Ultra-High Temperature Ceramic-Yielding Preceramic Polymers
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Technical Data Package Modernization for Information Assurance and Secure Data Exchange
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Multiple Telemetry Site Signal Source Synchronization
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Input-Output Unit (IOU) for Secure Processing and Routing of Hull, Mechanical, & Electrical (HM&E) and Navigation Signals
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• Fire Resistant Joiner Bulkhead
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• Fusion of Cooperative Information Sharing for Uncrewed Air Systems (FOCISAUS)
  Pre-release topic brief · USAF · STTR · Closes 2026-11-25
• G-TEAD USAREUR-AF ACE 27-02: Spectrum Enabled Warfare Powered by xTech
  Pre-release topic brief · Army · SBIR · Closes 2026-11-25
• Counter-Unmanned Aerial Systems Rapid Maturation
  Pre-release topic brief · OSD · SBIR · Closes 2026-11-25
• Intermediate Temperature Cooling Unit
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• AI-Enabled Computed Vision Air-to-Air Refueling Performance Assessment and Automated Pilot Debrief System
  Pre-release topic brief · USAF · STTR · Closes 2026-11-25
• Agile Wire Harness Manipulation and Installation for Unmanned Aerial Systems
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Luminescence-Based Surface Measurement Technique for Simultaneous Pressure and Temperature Measurements within Non-Oxygen Based Hypersonic Ground Test Facilities
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Long Rod Delivery System
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Shallow Jet Spurt Engineering Model
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Improved Cargo Door Actuator
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• Agile Autonomous Technical Data Package to Path Robotic Task Specification
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Reusable Illumination System
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Optimally Packaged Assembly for Laser Systems (OPALS)
  Pre-release topic brief · USAF · SBIR · Closes 2026-11-25
• Counter-Unmanned Aerial Systems Rapid Maturation
  Pre-release topic brief · OSD · SBIR · Closes 2026-11-25
• Cleaner for the Time Domain Reflectometer Tank Level Indicator
  Pre-release topic brief · NavalX · SBIR · Closes 2026-11-25
• Ground-Based Affordable Mass (G-BAM)
  Pre-release topic brief · DIU · SBIR · Closes 2026-12-23
• xTech|Kinetic Reach Competition
  Pre-release topic brief · Army · SBIR · Closes 2026-12-23
• xTech|Kinetic Reach Competition
  Agency SBIR topic brief · Army · SBIR · Closes 2026-12-23
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
  Agency SBIR topic brief · HHS · SBIR · Closes 2027-04-06
• NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
  Agency SBIR topic brief · HHS · SBIR · Closes 2027-04-06
• NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
  Agency SBIR topic brief · NIH · SBIR · Closes 2027-04-06
• NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
  Agency SBIR topic brief · HHS · SBIR · Closes 2027-04-06
• xTech|Search 10 Competition
  Pre-release topic brief · Army · STTR · Closes 2027-06-22
• xTech|Search 10 Competition
  Pre-release topic brief · Army · SBIR · Closes 2027-06-22
• Semiconductors
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Power Management
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Topics
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Medical Devices
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Internet of Things
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Instrumentation and Hardware Systems
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Digital Health
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Biological Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Artificial Intelligence
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Scalability Solutions and Accumulators
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Distributed Consensus and Fault Tolerance Mechanisms
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Digital Health Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Manufacturing Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Modeling and Simulation
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Cybermanufacturing
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Carbon Sequestration
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Communication and Networking Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Quantum Optics and Nanophotonics
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Photonic Materials
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Lighting and Displays
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Pharmaceutical Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Coatings and Surface Modifications
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Advanced Engineering Materials
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Health in Underserved Communities
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Bio-Inspired Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Animal Biotechnology
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Augmented Virtual and Mixed Reality Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Farming in Underserved Communities
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Building Analytical System for Learning from Dynamic Environments
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Sustainable AI Technologies for Low Resource Environments
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Edge Computing
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Convergence of AI and Cloud/HPC
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Biomedical Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Green Chemicals and Chemical Alternatives
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Food Processing, Chemicals and Agriculture
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Catalysts, Advanced Chemicals and Materials
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Monitoring Devices
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Other Novel Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Technologies for Trustworthy AI (safe, fair, transparent, privacy-preserving, explainable, and/or secure)
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Novel AI Hardware Technologies (e.g.: Neuromorphic Computing, High-performance Technologies for AI, Smart and Secure Edge Devices, etc.)
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Conversational AI Technologies
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07
• Polyculture Systems
  Agency SBIR topic brief · NSF · SBIR · Closes 2027-07-07

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